I have had a CTR, 350Z and an S2000 all great cars have to say the best out of all of them was the S2000, i know i'm in the minority here and it wasn't that the zed is a bad car, but the 2 of us just didn't gel. after 12 months i found the car a bit of a disappointment. by 18 months i'd sold it and swapped to the S2K. best move i ever made. i found the zeds engine note a let down, it looked faster than it actually was, had a plasticy interior. its the one car i don't miss after selling.
but if this is your first time in RWD cars then the 350Z is a great car to move to. although its RWD its a very predicatable drive, and when it does break away its fairly progessive (tyre dependent) and if you leave the TCS etc all switched on its very nannying and doesn't really let you get out of shape.
externally the zed is a great looking car and although i moaned about the plastic inside its far better than a lot of cars, and the kit levels not bad. its a comfy drive for most especially long distance i again am on my own on this but my hip could never find a comfy driving position for anything over a 3 hour drive. its a great GT car, has the low down grunt for overtaking on motorways. 270 bhp may seem alot but its well packaged in the zed and its not an out of control car. but treat it like a numpty with the toys turned off and you'll end up in a hedge.
as for the S2K yes i found it a much better drive, but it could be a little more tail happy than the zed, and it has a reputation as a widow maker, not sure why as i found it a very communicativ e and progressive drive. the S2k has a lot smaller cabin space, but it does make you feel like your squeezed into an F1 car. i prefer the leather and the dash in the S2K but its very minimal inside. although everything is right at your fingertips from 10 to 2 driving position. yes it lacks the torque that the zed has but for B road bombing and track work the stook is a dream to drive, the gear change is magic and its made for heel and toe work. (couldn't do it in the zed pedal setup was not right for my dodgy ankle) yes its more tiring on a long drive especially with a loud exhaust on.
i don't hate the zed but i always feel it should have been so much more, its a great car for modding, its a good safe start for learning RWD she's big she's planted, she's safe and you get a lot for your money.
as a driving car the S2K is the daddy i loved mine, has been one of my all time favourites to drive, very rewarding an di think more enjoyable if you have some RWD experience already.
the best advice is go try some cars out, see what you like. one mans whiskey is another mans dishwater.